Sentence examples for signalling operative from inspiring English sources

In this study, we review distinct aspects of Hippo signalling operative in the liver, discuss the impact of this pathway on proliferative control in different hepatic cell lineages, and evaluate the relevance of defective Hippo signalling to human liver cancer.

The Smad4 independence of the TGFβ Smad2/3 IKKα signalling pathway is reminiscent of another TGFβ signalling operative during erythroid development in which TIF1γ (also called TRIM33 or ectodermin) replaces Smad4 (He et al, 2006).

Here we reviewed the information arising from the recent unprecedented advancement made in the field of ABA signaling operative under calcium-dependent and calcium-independent pathways mediating the transcriptional reprogramming under short-term stress response.

Although both of compounds 12af and 12bf did not show strong antitumor efficacy in LS-174T nude mice model, they were promising candidates as Hh signaling inhibitors due to great potency against Hh signaling pathway and outstanding PK properties, deserving further evaluation in other Hh signaling operative tumor models.

In this manner a critical regulatory signal, operative at the DC-T cell interface, could be affected by AHR activation in DCs, ultimately influencing DC control of T cells.

Future work could usefully examine the upstream signalling networks operative in the cross-tolerance of heat and As stress.

It thus appears that in human CCs HH-GLI signalling is operative among epithelial cells (autocrine), while the previously described paracrine signalling may reflect the nature of the mouse model used (reviewed in Theunissen & de Sauvage, 2009).

The pathophysiology of obesity and type 2 diabetes mellitus is associated with abnormalities in endocrine signaling in adipose tissue and one of the key signaling affectors operative in these disorders is the nuclear hormone transcription factor peroxisome proliferator-activated receptor-γ (PPARγ).

Besides, the next higher proportion of proteins involved in signal transduction corresponds to the importance of various converging and diverging signaling pathways operative during plant development.

When working against a microbe, both signals were operative.

The first signal, he said, was "like the ignition switch," and the second "like the gas pedal". When working against a microbe, both signals were operative.