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Constitutive ET signalling, operating through TAK1/JNK-dependent and ALK5-independent mechanisms, is responsible for the persistent myofibroblast phenotype of SSc lung fibroblasts [ 18].
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HGF/c-Met signalling operates through many downstream targets, including PI3K/AKT and Notch in myocardium [8].
This suggested that Wnt/ β-catenin signalling operated downstream of Delta-Notch binding.
Indeed, the overlapping expression of multiple Wnt genes in the same tissues supports the hypothesis that Wnt signalling operates through a combinatorial code of different Wnt ligands [ 42].
In contrast to its direct effects on NH innervation, FGF signalling operates in a largely indirect manner to govern H-NH vascularisation.
However, the non-canonical signalling operates independent of β-catenin, but involves regulation of cytoskeleton dynamics by Dvl-dependent activation of Rac and Rho GTPases.
However, given that the Hh pathway regulates embryogenesis through stromal-mesenchymal interaction, several recent publications have provided compelling evidence that Hh signalling operates through paracrine signalling between neoplastic cells and the tumour microenvironment in many cancers [ 69- 71].
For example, the proto-oncogene Ha-Ras can stimulate or inhibit R-Smad signalling, operate upstream of TGFβ by promoting its auto-induction or act independently of the canonical TGFβ signalling pathway [ 6- 10].
The linkage between α2β1 receptors and membrane-associated synaptic proteins may position them within close range of the sites of NO release, which would be particularly important if NO signalling operates in discrete spatial dimensions (see below).
But at the present stage, we have to settle for analyzing relative signal strength of all RF signals operating at 433MHz within a proximity to the RF receiver station.
Simulation results and measurements of the chirp properties of converted signals operating at data rates of 2.5 and 10 Gbit/s are presented.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com