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The susceptibility tests with A. nidulans signalling mutants indeed point towards signalling pathways affected by NFAP.
Investigation of A. nidulans signalling mutants revealed that NFAP activates the cAMP/protein kinase A pathway via G-protein signalling which leads to apoptosis and inhibition of polar growth.
Axial changes in the segmentation circuitry were first suggested by the phenotype of Notch signalling mutants.
MN numbers in neural-specific Met signalling mutants.
Detection of Met-expressing MNs in the brachial spinal cord of Met signalling mutants.
Another auxin-mediated process is root waving, with transport and signalling mutants displaying abnormal patterns of waving [ 37, 54].
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This pattern was unique to eat-2 mutation-mediated DR as it was significantly different from the profile of low insulin signalling mutant, daf-2 e1370). daf-2 e1370
Based on results from this assessment, one of the PE2 cleavage-signal mutants, V3526, was determined to be the best vaccine candidate for further evaluation for human use.
It is known that BR signaling mutants or BR-synthetic mutants influence expression levels of BR-synthetic genes as a feedback mechanism (Tong et al., 2009; Duan et al., 2014).
Use of gibberellin (GA) biosynthesis mutants and BR signaling mutants to analyze the mechanism of action of this synthetic series indicated that the primary site of action is BR biosynthesis.
Metabolic profiling of signaling mutants uncovered links between chromatin-dependent phenotypes of ρ0 cells and metabolism of ATP, acetyl-CoA, glutathione, branched-chain amino acids, and the storage carbohydrate trehalose.
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