Whereas deficient HH signalling leads to birth defects, unrestrained HH signalling is implicated in human cancers2,4,5,6.
This study identifies how disruption of circadian glucocorticoid signalling leads to increased preadipocyte differentiation in 3T3-L1 celinesnes.
(f) Cartoon displaying the sequence of events by which integrin inside-out signalling leads to filopodia stabilization.
Increased EGFR signalling leads to the local activation of the PI3K/Akt pathway which, in turn, promotes filopodia formation in a RhoA- and FHOD3 formin-dependent manner9,10.
Indeed, the absence of Sema3E/PlexinD1 signalling leads to changed CR cell distribution in marginal zone/layer I throughout the developing neocortex.
Instead, there is increasing concern that when the host cannot clear an infection, continued interferon signalling leads to the induction of immunosuppressive pathways with the aim of limiting damage associated with chronic infection (reviewed in ref. 11).
BR signalling leads to the accumulation of BES1/BZR1 (BRI1 EMS SUPPRESSOR 1/BRASSINAZOLE RESISTANT 1) family transcription factors in the nucleus to control the expression of target genes for BR responses23,24,25,26,27,28.
They found that chondrocyte-specific activation of mTORC1 signalling leads to a shift from asymmetric to symmetric stem-cell divisions, and consequently to an increased number of stem cells in the resting zone.
Furthermore, ET-1-initiated cell signalling leads to short- and long-term injury, fibrosis and, ultimately, allograft rejection [36].
Indeed double deficiency in dVps4 and JNK signalling leads to the formation of neoplastic tumours.
Strikingly, simultaneous reduction of dVps4 and JNK signalling leads to the formation of neoplastic tumours.
