Sentence examples for signalling lead from inspiring English sources

Both NO and CNP signalling lead to the synthesis of cGMP, indicating there is cross-talk between IL-1β/NO/sGC/cGMP-mediated catabolism and CNP-mediated chondroprotection [ 31].

Probably these mechanisms are connected and contribute to the negative regulation of HIF1- α, because both reduction of ATP and inhibition of mTOR signalling lead to suppression of this transcription factor.

Although no correlate of protection to tuberculosis has been identified, the ability to generate IFNγ-producing T-cells has been shown to be important, as defects in IFNγ signalling lead to a high susceptibility to tuberculosis disease [ 19- 21].

These results are in agreement with the notion that high levels of Wnt signalling lead to the emergence of a cell population with posterior identities in the epiblast (Mazzoni et al., 2013; Tsakiridis et al., 2014) and raises the issue of the mechanism through which this is achieved.

Both phy- and cry-dependent signalling lead to an increase in HY5 levels (Osterlund et al, 2000), and while the phy-dependent mechanism for this observation is not fully understood, photo-activated cry1 inhibits COP1 in the nucleus, thus preventing HY5 degradation; this may be brought about through the translocation of COP1 into the cytoplasm (Yang et al, 2001).

Thus, loss of nFGFR1 and excessive nFGFR1 signaling lead directly to dysregulation of major developmental pathways.

Previous studies reported the activation of noncanonical Wnt signaling lead to inactivation of canonical Wnt signaling.

How does a reduction in TOR signaling lead to lifespan extension?

Additional regional specific signaling leads to interstitial fibrosis via collagen cross-linking in MIadjacent.

Activation of Wnt signaling leads to the progression of myopia in mice.

Han, X. et al. Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier.