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Intriguingly, mammalian Hippo signalling is also implicated in non-cancer diseases and plays a role in tissue regeneration following injury.
These observations suggested that Hippo signalling is also important for skin wound healing, although the MST1/2-LATS1/2 MST1/2-LATS1/2seem to plaxis key role[82].
Like c-fos, CREB signalling is also involved in pain processing, e.g. at the level of spinal cord in a study of tissue injury-induced inflammation and hyperalgesia [7].
Thus, NOTCH signalling is also required for this transition.
One interpretation is that decreased proBDNF-mediated signalling is also a necessary requirement for the formation of LTM.
Importantly, FGF signalling is also able to induce ectopic Duf expression in the dorsal region of all leg segments.
F11-mediated inhibition of RhoA signalling is also responsible for stimulating virus-induced cell migration, which may also help to enhance the spread of infection [28], [30].
While there is extensive evidence to support the role for gap junctions as a mechanism of glial wave propagation [45] [47], other studies have found extracellular signalling is also involved in glial wave [48].
Wnt signalling is also controlled by intracellular antagonists such as Axin, APC and Groucho which regulate β-catenin stability and activity [6], allowing fine control of signals triggered by Wnt proteins [8].
Notch signalling is also known to be an important player in L-R asymmetry, at the time when this asymmetry is first established around the Hensen's node (reviewed in [46]).
The cell signalling is also influenced by extracellular factors.
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