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Although LOX-1 is expressed at low level in normal conditions, its expression is highly activated by ox-LDL binding via intracellular signalling, indicating that pro-inflammatory conditions create a positive feedback that enhance endothelial dysfunction [9].
The distal axonal phenotype seen in flies lacking spichthyin is rescued by genetic manipulations blocking BMP signalling, indicating that enhanced BMP signalling is critical to its development.
What perhaps is surprising is that the absolute expression level of all of these factors would appear to influence the level of type I IFN signalling, indicating a level of co-dependency which we would not necessarily predicted.
Adhesion of eosinophils to fibronectin via VLA-4 [ 8] prolongs cell survival by Fas antigen signalling, indicating a role for integrin adhesion and signaling in regulating eosinophil function and death [ 10].
Papaya ACX protein shared high similarity with that from tomato, where a peroxisomal ACX protein is critical for the β-oxidation through JA biosynthesis and systemic wound signalling, indicating this gene might also be responsible for JA biosynthesis in papaya [ 42].
The latter role of PAI-1 is not solely explained by the protease inhibitor activity of PAI-1, but should rely on the ability of PAI-1 to alter cell signalling, indicating that PAI-1 can directly promote pro-proliferative and antiapoptotic signalling in a variety of cell types.
Similar(52)
This was an upside-down count signal indicating an odd number of clubs.
When the patient feels pain, he can send a signal indicating his perceived level of discomfort.
"It should be seen as a warning signal indicating that it's time to go get evaluated".
At one point, while listening to Salvador, the captain made a hand signal indicating that he was crazy.
For weeks before Bai Yun ovulated, she excreted chemical signals indicating that her fertile time was near.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com