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Thus we built on our existing modelling structure to include switch-like signalling in each pathway.
By this approach, we hypothesised that the level of pro-senescence signalling in each pathway can be measured.
Having shown previously that p65 nuclear translocation is a critical event in effecting the apoptotic response to aspirin (Stark et al, 2001), we next studied the effect of aspirin on NF κB signalling in each cell line.
We wished to assess how high-efficiency activation of Wnt signalling throughout the intestines would affect cell and tissue homeostasis, taking into account the underlying level of physiological Wnt signalling in each region of the bowel.
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However, the role of Hh signaling in each cancer type has not been completely established.
This would suggest a different requirement for IGF-IR signaling in each cell line.
We identified TNFα as a mechanistic trigger of the TNFR2-dependent activation of Orai3-Ca2+ influx and showed that CD11b/c cells are a potential driving source of this signaling in EACH hearts.
Together the data support the requirement of Hh signaling in patterning each of the mesoderm subtypes in the sea urchin embryo.
These results confirmed that the activation level of Wnt/β-catenin signalling fluctuates in each cell.
We used signalling questions in each domain to form judgments about the risk of bias.
The signal detected in each extract decreased linearly and appropriately upon dilution.
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