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This concept was also illustrated by the ability of upstream FGFR inhibitors to rescue downstream BRAF CFC mutations in zebrafish, presumably because reducing endogenous FGF signalling helped reduce the total MAPK signalling output (Anastasaki et al., 2009).
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Wnt signalling helps to maintain an undifferentiated state of the intestinal stem cells [16], [17] and, paradoxically, also regulates positioning, differentiation and maturation of Paneth cells [13], [18].
This is unlike the prolonged maintenance of pluripotency of ES cells in culture, where negative regulation of FGF signalling helps to inhibit lineage commitment.
That signal helped send stocks in Italy down sharply before both Italian and Spanish regulators said they would impose their temporary bans on short sales of stocks.
The second harmonic frequency ER signal helped us gain perspective on the extent of non-linearity and kinetics of the reflectance change in response to the potential modulation.
The discovery that protein phosphorylation is key to nerve cell signaling helped inspire the research of Kandel, 70.
The audio signals helped players determine enemy positions and direction of travel.
This was ameliorable, however, as inhibition of BMP and TGF-ß signaling helped to stimulate self-renewal as well as to stabilize Nanog expression (Wang et al., 2011).
Since the discovery of the epidermal growth factor (EGF) receptor in the early 1980's, 32 growing knowledge about ligands, activation, and signaling helped to understand its biological function.
And the ability to compress TV signals helps, too smaller signals can travel farther.
The low sensitivity to frequency offsets by the signals helps in reducing the burden of synchronization on the devices.
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