Sentence examples for signalling complex from inspiring English sources
Following TNFα stimulation RIP is recruited to TNFR1 signalling complex and is rapidly ubiquitinated with Lys63-linked polyubiquitin chains.
Alternatively, Wit could bind and interfere with a scaffolding protein required for receptor signalling complex formation.
All these reports highlighted protein-protein interactions as critical driving force of TCR signalling complex formation.
RIP is a component of TNF-induced signal complex I, but it also participates in death signalling complex II formation.
A provocative earlier study revealed the ability of Smac to be recruited into the lymphotoxin-β receptor signalling complex [ 52].
BMP receptor complexes comprising BMPRI and BMPRII oligomerise by different modes with the BMP induced signalling complex (BISC) to induce non-Smad signalling [ 24, 25].
TRADD (TNFR-associated via death domain) and FADD (Fas-associated protein with death domain) are also recruited to the receptor signalling complex to induce apoptosis.
Inhibition of caspase-8 within the death-inducing signalling complex or complex II, or within the Ripoptosome can trigger CD95L-mediated, TRAIL-mediated or TNF-induced necroptosis.
Therefore this signalling complex could offer itself for therapeutic intervention.
Interleukin-13 (IL-13) sequentially binds to IL-13Rα1 and IL-4Rα forming a high affinity signalling complex.
FADD next interacts with caspase-8 [5] and -10 [6] to form the death-inducing signalling complex (DISC).
