Sentence examples for signalling competent from inspiring English sources

Here we show that a subset of mutants at the NK1 dimer interface, such as the linker mutants Y124A or N127A or the kringle mutant V140A I142A, bind the MET receptor with affinities comparable to wild-type NK1 but fail to assemble a dimeric, signalling competent NK1 MET complex.

Consequently, their expression, subcellular localisation and signalling competent state must be strictly regulated.

The kinetics of Shc1 recruitment to endosomes precisely mimic the kinetics of p-EGFR arguing that the p-EGFR clusters are signalling competent.

Some gp130-cytokines, such as IL-6, homodimerize gp130 by first binding to their ligand specific α-receptor then to gp130 to form a signalling competent hexamer, whereas other gp130-cytokines, including LIF, CNTF, OSM and CT-1, heterodimerize gp130 with LIF-R to form signalling competent complexes [ 34].

More in depth studies on cells from Patient 1 showed that, upon treatment with BZ, CMG2 protein levels could be restored to approximate control levels, that the protein was properly targeted to the plasma membrane, and that it was signalling competent.

We present here a high resolution crystal structure of an ectodomain variant of human LGR5 (hLGR5ecomplexedlexed with a signalling competent fragment of mouse Rspo2 (mRspo2Fu1-Fu2).

The method relies on the display of the TCR, in its normal, signaling competent state, as a CD3 complex on the T cell surface.

HSP90 maintains such substrates in a signaling competent state, enabling them to receive upstream signals, such as hormone binding.

Engagement of the TCR by MHC-I bound antigenic peptides triggers profound reorganization of the protein and lipid composition at the IS, leading to the formation of signaling competent protein microclusters [16], [17].

Such stimulatory surfaces are widely used to mimic the formation of IS between APCs and T lymphocytes and to study TCR induced actin dynamics as well as the motility of signaling competent microcluster.

Concomitant to deployment of the AMP generating adenylate kinase isoform network, cardiac stem cell differentiation was associated with augmented AMP nucleotide signaling, increased expression of the AMP-sensor AMPKα2, a major cardiac isoform, and nuclear redistribution of the activated and signaling competent p-AMPKα(Thr172).