Signalling classes are identified as classes containing less than 20 proteins and containing at least one canonical protein.
They signal class and regional origins that people hold dear.
The Signaling class is responsible for generating and processing signaling messages.
These findings were concordant with genomic profiling of tumors the EGFR signaling class.
Among the 9 tumors in our PDGF signaling class, one had MET amplification and one had EGFR amplification.
The EGFR signaling class has prominent Notch pathway activation measured by elevated expression of Notch ligands, cleaved Notch receptor, and downstream target Hes1.
Conversely, chr7 gain without focal amplification of either EGFR or MET was most common in the NF1 transcriptomal cocluster (60.7% vs 23%, p = 1.6e−6), and this was concordant with aCGH profiling of tumors in the NF1 signaling class.
Compounds in the 'lipid signaling' class were placed in the 'lipid' class.
As expected, the majority of pathways exhibiting population differentiation, belong to the signaling class, including Calcium, MAPK, Toll-like receptor signaling, and others.
As regulators of G-protein signaling, class I phosducin-like proteins, which are involved in transmission of light signals in higher eukaryotes [ 44], represent viable candidates as nodes between the pathways transmitting light and nutrient signals.
Within the "Cellular processes and signaling" class, which lies between the two extremes, we also find the categories with more informational genes to have a higher expression context conservation than those containing operational genes.
