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The body of evidence for an intrinsic abnormality in ASM and its signalling characteristics in asthma is increasing rapidly.
We have considered, though, that ASM from asthmatics may have specific signalling characteristics due to genetic variation or epigenetic mechanisms, such that when maintained in standard culture media, differences between asthmatic and non-asthmatic ASM signalling will be apparent.
The observed hyperphosphorylation of the mutant proteins may contribute to the skewed signalling characteristics.
We are only beginning to understand which signalling characteristics encode the target gene expression.
Schmidt-Arras et al. proposed that ER associated phosphatases such as PTP1B contribute to the different signalling characteristics of the Flt3-ITD mutant receptor [ 26].
BIS20x3 could be isolated readily from quadroma culture supernatant and retained all the signalling characteristics associated with both of its chains.
Similar(47)
But anyone who knew the Waughs would not have failed to notice that Prendergast displayed a number of Arthur's signal characteristics.
He then spent a year painting in Mexico, which he later claimed gave him much of his insight into devising the starkness of lighting and simplicity of form that became two of his signal characteristics.
Signal characteristics follow CSF, with FLAIR suppression.
Thrombs have different signal characteristics, compared to the signal characteristics of brain herniation in vein sinus.
AFLT is a CDMA specific technology that uses the signaling characteristics of a CDMA to make a positioning determination.
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CEO of Professional Science Editing for Scientists @ prosciediting.com