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In this regard, it was not only an important, but also an unexpected observation, that the osteoblast-specific antagonism of Wnt signalling achieved through transgenic over-expression of Krm2 has such a tremendous impact on bone formation, thereby causing an osteoporotic phenotype, whose severity exceeds the one observed in Lrp5-deficient mice [11].
The many and varied functions of Notch signalling, achieved through activation or down-regulation, have been recently reviewed [ 31].
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Finally, functional experiments showed that activin/TGF-β signalling achieves this essential function by controlling the levels of transcription factors necessary for liver and pancreatic development, such as HEX and HLXB9.
An enormous suppression of ERK signal achieved maximal tumor growth inhibition in both B-raf and K-ras xenograft models.
Applying a 33.1 MHz with 1.4 Vp−p (−6dBFS) input signal, achieved SNDR is 61 dB resulting in 9.8 Bits ENOB with total power consumption of 42 mW.
The average recognition accuracy of unit saccadic signals achieved 99.0% (before sample optimization) and 99.57% (sample optimized) over 10 participants, which reveals that the proposed algorithm presents an excellent classification performance in saccadic signals recognition.
Here, a similar frequency and acceleration magnitude also served as a stimulatory signal, achieved in the absence of weightbearing, and thus the absence of directly applied matrix deformation.
Furthermore, the radioactivity signal from this tracer is lower than the signal achieved with more specific Aβ radiotracers, leading to difficulties in quantification [ 21].
The fetal signal achieved from the maternal abdomen typically has low amplitude and an unfavorable signal-to-noise ratio from which the FHR can hardly be detected [ 32].
The evaluation on the 19 out of 20 already-described signals achieved direct replication for 2 of the loci (11q23 and 18q21).
The specificity of the antibodies was confirmed in both the western blot analyses and the ELISAs by the low background and high signal achieved in repeated experiments using both methods and as described by the manufacturer (R&D).
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