Sentence examples for signaling thresholds from inspiring English sources

The approach of biasing cell activation by tuning signaling thresholds and outputs has applications to many dimeric receptor-ligand systems.

In contrast, there is emerging evidence that different signaling thresholds of a few extracellular signals induce different organs.

Hence, an accurate regulation of N and Ras signaling thresholds is critical for the acquisition of a progenitor fate.

We therefore propose a model in which the ECDs of LRP1b and LRP4 may modulate cellular signaling by scavenging and neutralizing extracellular ligands, thereby preserving signaling thresholds that are critical for proper embryonic development.

Testing PP14's impact on early responses during polyclonal activation of bulk T cells, we have previously demonstrated that PP14 preferentially inhibits Th1 responses as compared with Th2 [17], in accordance with their respective known TCR signaling thresholds [18] and as expected for a threshold-centered mechanism [13].

These findings suggest that the extracellular domains of both proteins may function as a scavenger for signaling ligands or signal modulators in the extracellular space, thereby preserving signaling thresholds that are critical for embryonic development, as well as for the clear, but poorly understood role of LRP1b in cancer.

CD19 regulates the intrinsic B lymphocyte signaling thresholds [ 22].

T-cell aging has been associated with resetting of signaling thresholds due to age-related changes in phosphatase activity [ 50, 51].