(e) Expression levels of Wnt/β-catenin signaling target genes (Axin2 and Lef1) were higher in Bmx/CA ECs compared with Ctrl ECs.
An age-specific gene expression response was present in both Wnt signaling target genes examined (Lef1 and Axin2), as well as in Sost expression in the LC mice.
Cotto-Rios, X. M., Bekes, M., Chapman, J., Ueberheide, B. & Huang, T. T. Deubiquitinases as a signaling target of oxidative stress.
Our results further demonstrated that in the postnatal and adult spinal cord, all ependymal cells express the Wnt/β-catenin signaling target gene, as well as Wnt ligands.
A further study found that maoecrystal I decreased the expression of Wnt signaling target genes, including c-myc, cyclin D1, survivin and Axin2 in colon cancer cells.
Overexpression of NICD1 activated transcription of Notch signaling target genes in AF, NP, and ATDC5 cells, and caused cell type-speci fic effects on expression of matrix anabolic and catabolic genes.
This could lead to maximal Wnt signaling target activation masking additional activation.
Consistent with this, SMAD2 phosphorylation, a downstream signaling target of TGF-β, was shown to be significantly increased following Wnt3a treatment (Figure 4B).
Finally, locostatin in RKIP-depleted and RKIP-deficient cell lines (HeLa and MEFs) had no effect on the EGF-induced activity of MAPK, a downstream signaling target of Raf.
Moreover, Asselin-Labat et al. found, during mid-pregnancy, a marked increase in RANKL expression in the luminal cell population, and the RANK receptor and the RANK signaling target Id2 in the MaSC-enriched basal cell subset [27].
The loss of proliferation noted in CKO lungs led us to measure the levels of c-Myc expression, which is known to be a ß-catenin/PITX2 signaling target gene [17] and key regulator of cell proliferation [36].
