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Consistent with these reports, our results demonstrated that CR caused activation of Akt/p70S6K1 signaling, indicating these altered signaling pathways conferred a beneficial effect on cell survival and age-delaying through regulation of p16 expression in response to nutrition deficiency.
The hundreds of radiomodulated genes identified were not a random collection, but belonged to functional pathways such as those of the cell cycle; cell death and repair; DNA replication, repair, and recombination; and transcription; translation; and signaling, indicating the strong cell reprogramming and double-strand break abrogation functions of ATM checkpoints.
NaCl, but not KCl, initiated G signaling indicating activation is caused by Na+ not Cl−.
Moreover, knockdown of AXL diminished EGFR downstream signaling, indicating a synergistic role for AXL in amplification of EGFR signaling.
Both PR1 and PR2 are also known to be associated with salicylic acid and ethylene signaling indicating their probable roles in modulating defense [ 49, 50].
In pancreatic cancer, inhibition of CDK5 kinase activity was found to suppress ras signaling, indicating a possible relationship between MEK/ERK and CDK5 activations.
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Studies of cellular signaling indicate that signal transduction pathways combine to form large networks of interactions.
This was an upside-down count signal indicating an odd number of clubs.
When the patient feels pain, he can send a signal indicating his perceived level of discomfort.
"It should be seen as a warning signal indicating that it's time to go get evaluated".
At one point, while listening to Salvador, the captain made a hand signal indicating that he was crazy.
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