Sentence examples for signaling compromised from inspiring English sources

We discovered that absence of PRLR signaling compromised the growth and differentiation of BAT in vivo and in vitro and reduced plasma concentrations and BAT expression of insulin-like growth factor-2 (IGF-2), which plays a central role in the control of placental and fetal growth [21], [22].

By co-culturing wild-type and different 'unfit' mouse ESCs for up to four days in differentiation-promoting media, they could show that cells with strongly reduced bone morphogenetic (BMP) signaling, compromised autophagy or with tetraploid genomes were selectively eliminated from mixed cultures, whereas they grew normally in monocultures [ 21 ].

It was also reported that ET signaling compromised the resistance to Fg in Arabidopsis, wheat and barley through premature senescence.

As soon as four hours after EP, Notch signaling compromised the epithelial morphology of treated cells, evident by the loss of their typical elongated, pseudostratified appearance, and induced cell delamination when compared to control embryos.

While an increase in the target might be helpful or benign, there is some risk that it would be interpreted as signaling a compromised Fed.

Thus, although certain non-autonomous defects of chdC nulls may be rescued by co-development with a small population of wild-type cells, the cell-autonomous pathways that are regulated by intracellular signaling remain compromised even in the presence of exogenous cAMP or wild-type factors.

Isaacs, J. T. et al. Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment.

To confirm this preliminary observation, we examined foxi3a-positive epidermal IC progenitors in an antimorphic allele of mind bomb mutants (mibta52b), which fails in lateral inhibition due to widely compromised Notch signaling and results in premature differentiation of neural progenitors and neuron mass-production [30], [31].

We assume that the observed striatal transcriptome changes are secondary effects of compromised DA signaling through nigrostriatal A53T-SNCA overexpression since human SNCA immunoreactivity in the striatum of PrPmtA and PrPmtB mice is detectable only in synapses, but not in neurites or cell bodies [13].

Dauer larvae with compromised LKB1/AMPK signaling rapidly depleted hypodermic fat storages and die prematurely due to vital organ failure [ 38].

Interestingly, despite the parallel phenotypes of MAA exposure and animal models of compromised estrogen signaling, MAA has been shown to enhance exogenous nuclear receptor signaling, including ER signaling (Jansen et al. 2004).