It will be worthwhile to explore in-depth the involvement of ICD in signaling activities in the submucosal space, specially its interaction with the activated macrophages and lymphocytes.
In addition to producing energy, mitochondria store calcium for cell signaling activities, generate heat, and mediate cell growth and death.
NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation.
We hypothesized that insulin analogues may elicit atypical proliferative and signaling activities in endometrial cancer cells.
In cells, Rhosin specifically inhibited RhoA activity and RhoA-mediated cellular function without affecting Cdc42 or Rac1 signaling activities.
Our recent study identified increased TGFβ protein and signaling activities in both human oral mucositis lesions and radiation-induced oral mucositis in mice (Han et al., 2013).
There are a variety of techniques for quantitative measurements of signaling activities.
Another advantage of QIC is the ability to quantify cellular signaling activities at subcellular resolution.
Such differential localization of signaling activities correlates with an inhibition of the late response, IL-2 secretion following prolonged stimulation.
To address the potential role of these genes, we examined Bmp signaling activities in our mutant mice (Fig. 4B).
One of the advantages of QIC is the ability to quantify cellular signaling activities with single cell resolution.
