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A number of promising advantages, such as low power consumption, low cost, low complexity, noise-like signal, resistant to dense multipath and jamming, and excellent time-domain resolution, have made UWB systems perfectly suitable for personal computing (PC), consumer electronics (CE), mobile applications, and home entertainment networks.
Aging cells are over-activated, hyper-functional (for example, hyper-secretory) and secondary signal resistant [ 18].
Senescent cells are hyperfunctional, hypersecretory, pro-inflammatory and signal resistant (e.g., insulin resistant).
Immunoblots revealed that cells exposed to hPrP90-231 retain a 3F4-immunoreactive signal, resistant to PK digestion (up to 0.5 μg/ml, upper panel), whereas vehicle-treated cells showed an almost complete loss of 3F4 signal.
Aging by itself is a selective force that favors cancer probably because aging cells are signal resistant, thus providing selective advantage to cells that by-pass the need in mitogenic signals.
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Inactivating mutations of its components, which may occur in cancer, makes MTORC1 signaling resistant to amino acid deprivation.
Perhaps expectedly, while the sensitive cell lines depend on the ErbB-dependent signaling, resistant ones circumvent this pathway and, at least in some cases, rely on the Ras pathway.
Additionally, it was reported that GLY1-encoded GAPDH plays an important role in plastidal oleic acid-mediated signaling and resistant signaling in Arabidopsis (Kachroo et al. 20042005; Chandra-Shekara et al. 2007; Xia et al. 2009).
Not surprisingly, cells from old individuals can be signal-resistant.
Senescent cells are hyper-active, hyper-functional (for example, hyper-secretory phenotype or SASP) compensatory signal-resistant, secondary malfunctional and eventually atrophic [ 28, 36- 38, 50- 55].
Functionally, this means that cells expressing CD152 on the cell surface and receiving a CD152 signal are resistant against activation-induced cell death [11].
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