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Speech is a critical communication signal for the development of social skills and language function.
Recent studies in rodents have illustrated the plasticity of arcuate nucleus projections in the neonatal period and have described a role for leptin as being a neurotrophic signal for the development of hypothalamic circuits [43], [44], [45].
It is a crucial signal for the development of enteric neurons [ 14– 14].
Furthermore, microtubule de-acetylation was recently shown to be an early signal for the development of growth-cones in neuronal remodeling associated with regeneration (Cho and Cavalli, 2012).
It is noteworthy in this context that transforming growth factor beta is an important instructive signal for the development of both Th17 and iTregs.
In animal models of insulin resistance, the expression of RBP4 was strongly induced in adipose tissue, and systemic release of RBP4 appeared to be a crucial signal for the development of systemic insulin resistance [ 10, 12].
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The objective of this study is to develop a reliable and robust analysis system that can automatically detect motor imagery (MI) based electroencephalogram (EEG) signals for the development of brain computer interface (BCI) systems.
Our results are consistent with the suggestion that Ag-specific Th1 cells and their derived cytokines, IFN-gamma and IL-2, and Th2-derived IL-10 together with IL-6 produced by macrophages provide important signals for the development of mucosal IgA and serum IgG subclass responses in the absence of preferential expression of Th2 cytokines IL-4 and IL-5.
The DNA is not the blueprint of life; rather, it contains many of the basic codes and signals for the development of an organism.
Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of its activity along the entire antero-posterior axis has not been performed in this germ layer.
10.7554/eLife.02743.015 Figure 5. Importance of aromatase signaling for the development of sexually dimorphic MeA responses.
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