Exact(6)
By controlling the cooperative assembly of signaling complexes that play positive or negative roles, LAT ensures signal diversification [6], [7], [8], [9].
ErbB receptor heterodimerization not only leads to signal amplification, but also results in signal diversification.
They also contribute to signal diversification by channelling the information from activated receptors into signalling pathways with distinct biological functions.
Inhibiting both receptors may be particularly attractive as interactions between HER2 and EGFR provide a mechanism for signal diversification and augmentation (Konecny et al, 2006).
Essentially, all pairwise combinations of the four receptors can be induced by the 10 specific ErbB ligands characterized to date, generating a great potential for signal diversification.
Epidermal growth factor receptors are commonly active in a dimeric form and interaction between different EGF receptor pairs represents a mechanism for signal diversification and amplification (Olayioye et al, 2000; Yarden and Sliwkowski, 2001).
Similar(54)
The use of bacterial larvicides against malaria and dengue signals a diversification of vector control methods in some countries.
Widespread appearance of domain structures in organismal lineages across the three superkingdoms signals massive diversification of proteins and proteomes.
On the other hand, as indicated above, we suggest that interpretations of the signals of diversification mode inferred from relative disparity through-time analyses should be based on multiple factors, rather than on the extent of subclade overlap in morphospace (i.e., the MDI value) alone.
A comparison between the rodent fossil record and our results suggest that extinction led to the loss of diversification signal for most of the Paleogene nodes.
Comparison between the rodent fossil record and our results suggest that extinctions led to the loss of diversification signal for the Paleogene nodes.
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