The marked bias towards a 5′- T seen amongst some cancer singlet C mutations suggests that kataegis might be signalling a much wider implication of APOBEC-mediated deamination in genome-wide mutagenesis in some tumours.
If the numbers turn out to constitute a trend, it could signal other social implications: modestly reviving the multi-generational family and further delaying marriage and childbearing.
D'Esposito, M., Deouell, L. & Gazzaley, A. The impact of alterations of neurovascular coupling on BOLD fMRI signal: implications for studies of aging and disease.
D'Souza, V. et al. Identification of a high affinity nucleocapsid protein binding element within the Moloney murine leukemia virus Psi-RNA packaging signal: implications for genome recognition.
Analogous mechanisms are here implemented in a variety of CTRNN architectures and are shown to increase node sensitivity and improve signal propagation, with implications for robotics.
Indeed, VEGF signaling has important implication for apoptosis resistance, and enhanced survival of B CLL cells [ 21].
But the deal could also have broader implications, signaling a weakness in Boeing's marketing plans and potentially threatening some of Boeing's relationships in a country that has invested billions of dollars in helping develop its planes.
Binge drinking upregulates accumbens mGluR5-Homer2-PI3K simplicationsnctional implications for alcoholism.
Courtois, G. & Gilmore, T.D. Mutations in the NF-κB signaling pathway: implications for human disease.
Guruswamy, S. & Rao, C. V. Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.
Results of their research, published in the Dec. 13 issue of Science Signaling, have implications for figuring out what triggers the metastatic spread of cancer cells and wound healing.
