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Dr. Pritchard's test measures the difference in DNA diversity between those who carry a new gene and those who do not, and a significantly lesser diversity is taken as a sign of selection.
Despite the fact that our zebrafish strains show no sign of selection for or against homozygous fmr1 mutants, this is an option that is difficult to eliminate.
Depending on the sign of selection, the propagator ratio g(x) increases or decreases without saturation.
Polymorphisms within the sampled CRt population implied the existence of several strain variants, and showed mutational patterns that might be a sign of selection on synonymous sites.
The sign of selection acting on the sequences was assessed using the ratio ω of the relative rates of nonsynonymous to synonymous nucleotide substitutions per site.
This can be interpreted as a sign of selection (positive or purifying) or of varying mutational opportunities for insertion and deletion.
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We selected three of these to look for signs of selection in the African buffalo (Syncerus caffer).
"The signs of selection are indeed persuasive," Rocha says.
Signs of selection on short timescales will always be prey to statistical fluctuations.
Researchers are tracking changes in our bodies and seeking signs of selection in the genome to find out.
Now a team of scientists at the University of California, Irvine, has used a new computational approach--the "linkage disequilibrium decay" test--to search for signs of selection over the entire human genome.
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