We determined the sign of the module eigengene to be positively correlated with the majority of genes in the module and refer to this majority as the positively-correlated module genes.
Another control register is required to control the sign of ADD/SUB module used in the next CORDIC stage.
Since only clustered MCCs are of interest in providing a sign of breast cancer, the second module, called the MCCs Finder Module, finds and locates suspicious areas of clustered MCCs, called regions of interest (ROIs).
Our work is related to previous work on the sign of interactions in transcription modules [ 16] and biological network subsystems [ 17].
Since we assembled these modules using a signed network, the sign of the correlation is equivalent to the direction of expression change with respect to the trait.
We define eigengene networks using the signed adjacency (Eq. 26) because we find it useful to preserve the sign of the co-expression information between module eigengenes.
Given the exceptionally high correlations between the individual MM measures, it made sense to combine them by forming a weighted average, which flipped the sign of the negatively related green CTX module.
Rather, the absence of any detectable sign of expression conservation in this co-module suggests that different genes are involved in olfactory function in mouse and human.
Furthermore, we introduce a low-overhead module to reduce the relative error and a sign correction module to fix the sign error.
Some periods of decrease in the module of SYM-H could be attributed to the changes in the sign of IMF Bz.
