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Whereas physicians appropriately err on the side of over-diagnosis, thereby assuring they don't miss a case, surveillance case definitions appropriately err on the side of specificity, thereby assuring they do not inadvertently capture illnesses due to other conditions".
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Mr. Keigwin comes down on the side of nongender specificity, as the language of the day has it.
This suggests that JointSNVMix2 is erring on the side of recall versus specificity when compared with JointSNVMix1, though the performance is not dramatically different.
Because hydrogen abstraction from an unactivated primary carbon atom requires a high level of specificity, side reactions with lower energy barriers and/or products that are thermodynamically favored are highly competitive.
Current therapeutic approaches which include surgery, chemotherapy and radiotherapy are associated with adverse side effects arising from lack of specificity for tumors.
But this is not because these drugs have been optimized in terms of specificity and side effect profile.
Despite proteasome inhibitors' lack of specificity, the side effects of bortezomib are surprisingly limited.
First-generation (aminoglutethimide) and second-generation (fadrozol and formestane) AIs are no longer used because of problems caused by their low potency, lack of specificity and side effects, especially with aminoglutethimide (Holzer et al., 2006).
A senior State Department official said the American side was surprised at a lack of specificity in an opening statement by Mr. Lavrov in Geneva, which prompted American experts to insert detailed provisions and deadlines to try to turn it into a workable plan.
Cytotoxic chemotherapy or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects because of the lack of specificity to target cells alone.
Screening of MMPs specific inhibitors has gained attention recently but due to their monomodal nature, lack of specificity and greater side effects there is a need to develop therapeutic strategies focusing on prophylactic agents [ 45].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com