Considering the millions of potential SNVs whole genome data yield and the desire to recover potentially rare and complex events, SV detection methods can afford to err on the side of sensitivity.
While researchers have made great advances by improving the brightness, spectral coverage, and biocompatibility of fluorescent probes, these only address the signal side of sensitivity (signal-to-noise ratio).
It has been argued that self-report questionnaires tend to err on the side of high sensitivity rather than high specificity, and tend to over-estimate the prevalence of psychiatric disorders [ 96, 97].
Migraine (usually characterized by severe pain on one side of the head, sensitivity to light and/or sound, and nausea).
Fraser had played nine Tests for his country over the course of 1994 but fell victim to chairman of selectors' Ray Illingworth's desire to freshen up a struggling side, and the lack of sensitivity the famously hard-nosed Yorkshireman applied to his role.
While the public expressed strong preference toward lowering severity of side effects, improving sensitivity of the test had by far the largest influence on patients' decision to use genomic testing.
The study required 160 events to have CIs that did not exceed 10% on each side of the point estimate of sensitivity and specificity if sensitivity was 90%, specificity was 55%, and 40% of events were truly of international public health concern.
However, in most cited reports from expert centers, the probability of cure without IOPTH monitoring is 95% or more among localized cases, confining these institutions to the far right-hand side of the two-way sensitivity analyses.
The flip side of this optimisation in sensitivity is a blunting in specificity, whereby it may become unclear whether the identified organism is indeed the cause of the clinical condition.
The added value of directly using PODs for the computation of optimal sensor locations is the computational efficiency of the method, side-stepping the tedious computation of sensitivity coefficient Jacobian matrices and using only system responses and/or experimental results directly.
A role for host markers in guiding therapy may persist, but it will be limited to evaluation of sensitivity to side-effects of the drugs.
