The measure of serious side effects reflects lifetime experience and does not afford a view into the effects on HRQOL of temporally proximal versus distal harms; nevertheless, for those on methotrexate, intolerance is measured for a time period that directly relates to study outcomes.
There is a conception that glucocorticoids' anti-inflammatory effects are attributed to GR-regulated transcriptional repression, while the side effects reflect transcriptional activation by GR.
The reported side effects reflect the known safety profile of bendamustine.
Based on work on Drosophila, phenotypic plasticity of pigmentation has recently been proposed to be a side effect reflecting the impact of temperature on epigenetic mechanisms (Gilbert et al. 2007).
Scattering from untreated material exhibits strong features due to interference effects reflecting side-to-side ordering of cellulose fibrils.
Cataracts were associated with an increased risk of medication side effects, possibly reflecting ability to read labels and instructions and comply.
If efficacy and adverse reactions occurred at similar doses, this raises concerns as to whether the minimal effective concentration was reached in all patients – no side effects might reflect noneffective drug concentrations.
The new guidelines reduce the likelihood of side effects, and reflect "the best evidence-based practice on what is safe and effective," according to Daniel Grossman, a professor of obstetrics at the University of California, San Francisco, who studies contraception and abortion.
Many transfection reagents, however, are known to exhibit substantial toxic side effects, as reflected by cell viability assays.
A 1-year, 2-year and 3-year OS, ORR and side effects are reflected by OR, which was calculated by using a method reported by Mantel and Haenszel.
