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The prevalence and severity of side effects increased with increasing level of follow-up.
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The precautions followed in prescribing medication for the elderly are an excellent example of the principle that should govern all drug therapy drugs should be used in the lowest effective dose, especially because side effects increase with concentration.
The side effects increase with duration and dose.
This means that the occurrence probability of cumulative side effects increases with the number of prescribed drugs.
Commonly, SRS is limited to smaller treatment volumes to prevent high incidences of radiation-induced injury; it is known that the risk of treatment-related side effects increases with target size as well as an increase in RT dose.
With regard to dosage, it is important to remember that the risk of side effects increases with dosage and that tolerability is a relatively greater concern in the elderly – thus the axiom "start low and go slow".
This is an important observation that deserves more detailed research, since some side effects appear very early after initiating medication, sometimes even before therapeutic effects, and diminish over time, whereas other side effects increase in frequency and severity with increasing treatment time.
It is plausible that with extended duration of diabetes, the systemic side effects increase.
Vasomotor and musculoskeletal side effects were increased with the use of anastrozole, and these side effects were also reported by many women on placebo.
These studies demonstrated that the efficacy was similar at the two doses but that the side effect profile increased with the 500 mg dose, with a 15% chemotherapy toxicity criteria grade 3 to 4 toxicity [ 5- 7].
Post hoc analysis of the FREEDOM trial, which showed that denosumab reduces the risk of fractures in patients with osteoporosis, did not report a difference in side effects with increasing levels of renal insufficiency.
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CEO of Professional Science Editing for Scientists @ prosciediting.com