Bipolar patients who are currently depressed consistently endorse greater side effect burden than euthymic patients.
Still, few large studies have investigated the overall side effect burden of antipsychotics in real-life settings.
Combining a mood stabiliser with an AAP may have therapeutic benefits, but these must be weighed against the additional side effect burden.
That means the treatment not only improved the TN symptoms, but also showed an improvement in the quality of life, emotional function, side effect burden.
Because of this, consideration should be given to more aggressive treatment of depression to alleviate some of the subjective side effect burden before considering dose changes or adding antidotes.
Success in the introduction of novel, effective and safe analgesics has been notably limited over the past ten years even though existing treatments have low responder rates and a high side effect burden.
In evaluating physical complaints from any specific patient, three factors should always be considered: (1) misattribution of symptoms for side effects; (2) the effect of the mood state itself specifically depression on subjective side effect burden (Gitlin et al. 1989; Wilting and Heerdink 2009).
Because of its side effect burden, narrow therapeutic window, and an increasing pharmacopeia, there are clinical situations in which lithium is no longer a first line treatment and/or when toxicity necessitates drug discontinuation (Malhi et al. [2012]; McKnight et al. [2012]).
In a prospective study of 246 elderly subjects taking the SSRI paroxetine, CYP2D6 genotype was not associated with side effect burden [10].
For those who left Level 1 for further treatment but did not want to continue with citalopram, their phenotype was probably tolerant, probably intolerant, or intolerant based on the level of side effects at the study exit based on the Global Rating of Side Effect Burden [22].
Sunitinib is associated with a significant side effect burden.
