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So if people with depression show classic sickness behaviour and sick people feel a lot like people with depression – might there be a common cause that accounts for both?
Sickness behaviour is a set of behavioural changes that develop during infection, eventually leading to decrease in mobility and depressed behaviour.
However, sick vertebrates often show a decreased appetite, part of the well-studied sickness behaviour [ 7].
Cytokine-induced sickness behaviour: mechanisms and implications.
The results showed that LPS induced sickness behaviour every week.
Dantzer R (2004) Cytokine-induced sickness behaviour: a neuroimmune response to activation of innate immunity.
Lipopolysaccharide (LPS) induces a depression-like state in animals that mimics sickness behaviour.
The present study was designed to explore the potential of caffeic acid against LPS-induced sickness behaviour in mice.
That feeling of being too tired, bored and fed up to move off the sofa and get on with life is known among psychologists as sickness behaviour.
Our findings suggest that, as seen in animals, psychological and immune stressors may act synergistically to promote inflammation and sickness behaviour in humans.
LPS increased the systemic and brain cytokine levels, altered the anti-oxidant defence and produced key signs of sickness behaviour in animals.
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