Three of them are human pathogens: Trypanosoma brucei, responsible for the African human trypanosomiasis also known as sleeping sickness, Trypanosoma cruzi, the agent of Chagas' disease in Latin America, and Leishmania sp., responsible for leishmaniases in many countries throughout the world.
The causative agent of sleeping sickness was never established, although the influenza virus was suspected.
We give an overview over the various views, the workflow concept and present an exemplary analysis of screening datasets targeting T. cruzi and T. brucei, the causative agent of sleeping sickness and Chagas disease, respectively.
The PLP-dependent enzyme ornithine decarboxylase (ODC) is a target in the fight against African trypanosomes, the causative agent of sleeping sickness, and against cancer [2], [6], [7].
Trypanosoma brucei is the causative agent of sleeping sickness in man and nagana disease in cattle and one of the most divergent eukaryotes from mammals.
Trypanosoma brucei is the causative agent of sleeping sickness in humans and N'gana in cattle, and has a major economic and morbidity impact across much of Africa [ 1].
As the causative agent of sleeping sickness, a fatal tropical disease, Trypanosoma brucei (figure 3f ) has been the subject of intensive molecular and cell biological investigations aimed at vaccine and antiparasite drug development.
We used publicly available data from Trypanosoma brucei, causative agent of sleeping sickness, and an original dataset from Saccharum officinarum (sugarcane), an important biofuel source, to illustrate several points in typical metabolomics analysis sections.
The diversity of peroxisomal functions is well exemplified by atypical peroxisomes, termed glycosomes, which compartmentalize the first seven enzymes of glycolysis and which are indispensable for the survival of Trypanosoma brucei, the causative agent of sleeping sickness [ 3].
However, taken together with alleles at the APOL1 gene, the data are consistent with a role of the HPR locus in increased resistance to T. b. gambiense sleeping sickness as a possible selective agent by increasing the effectiveness of TLF-1.
