Sentence examples for sick interaction from inspiring English sources

If two separate genes with mutations that are viable in a single mutant cause a cell death or sickness, then we call the situation a synthetic lethal or sick interaction and edges in the network are created based on this information.

I wondered whether it was my pride, my country's pride or those Hasidic gentlemen's at stake in this sick interaction.

In addition, a synthetic sick interaction was observed between the ΔrbbA mutant as donor and ΔyhjD as recipient or vice-versa (Table S2).

GAT2 encodes for a poorly characterized putative zinc finger transcription factor, while LEA1 gene product is involved in RNA splicing, although its null mutation shows synthetic sick interaction with several cell wall related genes, such as CHS1 or CHS5 [ 40].

Unlike classical "synthetic lethal or sick" interaction screens in yeast, our strategy allows us to analyze interactions of Drosophila mis-expression alleles with a "hypomorphic" allele of His1, which affords several advantages.

Indeed, based on associated proteins and synthetic sick interactions between urn1Δ and mutations in S. cerevisiae its3, isy1, pml1 and snu66 [58], and dre4Δ with S. pombe splicing mutants shown here, the most parsimonious explanation for ScUrn1/SpDre4 function is as a splicing factor.

Possible synthetic sick interactions were confirmed by a spotting assay explained in [ 50].

Confirmation tests led to the identification of 25 synthetic dosage lethal or synthetic dosage sick interactions.

Also, combinations of mutations that fall short of killing the organism, but render it incapacitated in some way – so-called 'synthetic sick' interactions – can also reveal important information about gene function.

Likewise, the number of negative genetic or synthetic sick interactions (SSI) between the As-set and the genome was not significantly different from that between the MS proteome and the genome (supplementary material Fig. S3B,C).

Differences between the data-sets with regard to physical, genetic and synthetic sick interactions were assessed by empirical p-values by comparing the median difference between observed groups with 1,000,000 random permutations (without replacement) of the pooled data.