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13 male and 18 female, age matched, sibling paired mice were tested (total 31 mice) per group.
Ucp1KO [ 22] and wild-type sibling paired mice were used at age 7 12 months.
Mice (sibling paired males aged 3 5 months) were housed individually in specially built plexiglass cages and were acclimatized for 72 h before data collection.
Female Wistar rats (Charles River Laboratories, UK) and Ucp2−/− [4] and wild-type sibling paired mice were 10 12 months old.
Heterozygote matings were then set up to generate sibling paired mice of the following genotypes of the double NNT and UCP2 knockout model; WT, Ucp2KO, NntKO and Ucp2KO/ NntKO.
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Selected sibling pairs included 250 proband-sibling pairs from 192 families.
Because of school separation, sibling pairs face independent health shocks from own school peers.
The study included 497 case control pairs (427 case-unaffected sibling pairs and 70 case-unrelated control pairs).
Results: Sibling pair differences in relative reinforcing efficacy of food were associated with sibling pair differences in zBMI (p = 0.046); this effect was moderated by delay discounting (p < 0.002).
This study was designed to test the association of sibling pair differences in relative reinforcing efficacy of food and delay discounting on sibling pair differences in zBMI scores of same-gender zBMI-discordant siblings.
Sibling pairs with greater differences in relative reinforcing efficacy and delay discounting had greater differences in zBMI.
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