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Additionally, four types of shuffling reference sets which consisted of 1,000 shuffled pseudo pre-miRNAs that preserved not only the stem-loop structure but also the exact or nearly exact mononucleotide and dinucleotide frequencies as real pre-miRNA are generated for each miRNA.
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The relative values of the bottom panel are the logarithm of the ratio between the observed largest connected component and the shuffled reference model, where call times do not correlate with network structure.
In the remaining, we will refer to these references as respectively the "uniform" and the "shuffled" references.
Thus, to have a control with an identical nucleotide composition as in the 3'UTRs we pooled the 3'UTR sequences, created ten randomly shuffled references, and counted the number of times the motifs were present in each of these.
The wonder is that he surpasses them, and that "Breathless," quoting from so many other movies (and shuffling together cultural references that include Faulkner, Jean Renoir, Mozart and Bach as well as Hollywood movies), still feels entirely original.
Like a Shakespeare play, you're thrown right into the middle of a story, with only the tone of the start screen for context — like, "What's all this lightning?" The story unfolds over the course of a painfully slow 5-10 minute cut scene of sprites shuffling around, and references to an array of names and places you have no idea about.
The significance of dataset distances was estimated by constructing a parameter reference distribution by shuffling tissue-specific genes among datasets.
If the progenote genome was made of modules yet to be assembled into functional units, introns would have played an essential role in the formation of early genes by exon shuffling [[ 56] and references therein]; indeed, the gene-protein structure correlation postulated by the exon shuffling theory appears stronger in the subset of introns that are most likely to be ancient [ 56].
During the roast, Pam says Michael's penis is so small, "If it were an iPod, it would be a Shuffle", a reference to the smallest of the Apple Inc. portable media player brands.
"Constantly sifting, shuffling, combining features, viewing as indexical references within a database eigenfaces seem to do that.
In recent years, there has been an increasing number of studies focusing on the role of chromosomal reorganizations in adaptation and speciation processes [ 1– 4], and more specifically on the influence of genome shuffling in recombination ([ 5] and references therein).
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