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Our shuffling method frequently does not remove the signal, since the shuffled sequence often still has an RNAz score above our cutoff threshold.
Our proposed shuffling method is illustrated in Figure 6.
In order to improve the performance of the shuffling method, GA is used to select a proper pair of.
Experiment 1 studied the effect of segment shuffling method to the perceived fluency and naturalness of the synthesized audio texture.
Additionally, in order to check that our results are not affected by systematic sampling bias, we analyzed the same sets of impact trajectories in panels (A-D) using a shuffling method to destroy the author-specific correlations across time.
It is suggested that an effective DNA shuffling method combined with a high-throughput screening method will provide the technical solutions for engineering proteins in basic and applied scientific applications.
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This similarity provides a means to genetically engineer the PKSs by directed gene shuffling methods.
To rule out the effect of base composition bias on robustness, four types of reference sets for each real pre-miRNA are made using four different sequence shuffling methods: mononucleotide shuffling, dinucleotide shuffling and shuffling based on a zero and first order Markov model.
Two shuffling methods have been applied to build a library of increasing complexity ranging from bi- or tripartite chimera up to highly mosaic structures (average 5-6 crossovers per sequence).
The codon shuffled method above cannot capture selection for stability in non-coding regions surrounding ORFs.
These results also demonstrate that the different types of shuffled methods are indistinguishable.
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