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Shuffle, the first approach that deliberately exploits the MIM capability, suffers from the usual drawbacks inherent to the centralized approaches.
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Similarly, LOC_Os03g12580 was formed from shuffling the first exon of LOC_Os06g01010 and its flanking sequences (supplementary fig. S2 P, Supplementary Material online).
For each species, we randomly shuffled the first 50 codons of each coding sequence, and we repeated this process 100 times for each gene.
The empirical distributions of the optimal scores observed by shuffling the first genome depend a lot on the nature of the substitution scores between the genes of the first genome and the genes of the second one.
Candidate associations are then evaluated statistically by a permutation test, which calculates the p-value which is the proportion of scores exceeding the original LS score after shuffling the first series and re-evaluating the LS score many times, and by the false discovery rate (FDR q-value), which is used to correct multiple comparisons.
Sometimes, when the shoe is shuffled, the first card turned over will reveal how many cards the dealer should "burn" (toss away) in between deals for each hand.
The first is the emergence of new domain architecture through domain accretion and shuffling, the second is deletion of genes, and the third is the expansion of a gene family either by gene duplications or by retropositions.
Coach John Muckler shuffled the Rangers' second and third lines last night to complement the Czech line, but the result was predictable.
Apple could be about to kill of the iPod Shuffle, the second classic iPod to be discontinued in a year.
To obtain empirical distributions, we first randomly shuffle the samples between groups, then calculate T-statistics in permuted samples, and finally merge T-statistics from all transcripts without any averaging as one whole empirical distribution.
There was Barry's awkward finger snapping and foot shuffling at the first grade father-daughter dance contest.
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