Starting with network N G, we shuffle node labels with all other genes targeted in the screen to create a shuffled version of N G we refer to as.
In a subsequent paper titled "How many shuffles to randomize a deck of cards?", L.M. Trefethen and L.N. Trefethen argued that by measuring the approximation to randomness with entropy instead of total variation distance, it takes only approximately log2n shuffles to randomize a deck of n cards.
We shuffled the order of genes in the genome 1000 times and obtained the distribution of n in the randomized data.
Persi Diaconis and David Aldous proved in 1986 in a paper titled "Shuffling cards and stopping times" that the cutoff time for this shuffle is n log n, where log n denotes the natural logarithm of n.
To determine the value of N, we compared domain numbers under different thresholds (N) in human and mouse, and used the control group by randomly shuffling the locations of all genes along chromosomes (1000 times; Supplementary Fig. S2A).
The latter were generated from 100 n shuffles (where n = length of UTR) for each of the original UTRs to create 100 n different sequences and calculating a mean value for the number of uORFs.
Small production fluctuations, such as those related to cell culture pH, temperature, and media ingredients, also may impact the final product, introducing micro-heterogeneities such as alternative disulfide pairings/disulfide shuffling, deamidation, (methionine) oxidation, crystallization of N-terminal glutamine residues, and partial enzymatic cleavage [ 8,43 45].
Spontaneous activity patterns are significantly lower-dimensional than shuffled controls (n = 27 experiments of 10 animals, p = 0.01 one-sided test).
(Petrusich) BOYZ II MEN (Tuesday and Wednesday) Years before the synchronized croon and shuffle of 'N Sync and the Backstreet Boys supplanted grunge on pop radio, Boyz II Men, from Philadelphia, rejuvenated boy-band shtick with their earnest, bellowing ballads.
This was a shuffle of 74 officers.
The big Detroit shuffle of 2005.
