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Notably, this effect was significantly exacerbated by addition of the Pin1 small molecule inhibitor PiB (Uchida et al, 2003): mammosphere formation efficiency of Pin1 +/+ shrunk progressively and was reduced by almost 50% at the stadium of quaternary mammospheres (M4) and did not reach the M5 level.
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As the length scales being examined in these studies have progressively shrunk, progress in interpreting the nanoworld has become increasingly dependent on techniques capable of nanoscale measurements within physiologically relevant environments.
The spindle shrank progressively and ended up as small asters (Fig 4A, lower panel).
A recent Bayesian infinite sparse factor analysis model (Bhattacharya and Dunson, 2011) circumvents the selection of a fixed rank for K2 by assuming in principle an infinite number of columns in the Λ matrix; however, the columns shrink progressively such that only the first ranks are influential in practice.
Including 106 to 137 genes, the gene repertoire appears to have progressively shrunk from charophycean green algae to land plants [ 20, 22].
Both groups could borrow time against future rounds, but the poor borrowed far more, progressively shrinking their future paychecks while the rich mostly avoided debt.
In the three years that Mr. Gorman, 54, has been at the helm, the bank has been progressively shrinking its business of trading bonds, commodities and other investments and expanding into wealth management.
By progressively shrinking the number of hours worked a week, or years worked over a lifetime, society seemed to be rolling towards some sort of ideal, with vin rosé and deckchairs on the beach for all.
But it was also about more: my world progressively shrinking to a small, sterile, asteroidal universe between the interminable nausea and the chemobrain that left my head both empty and feverish, between survival and death.
This thermal budget control issue gets more crucial as the technology node progressively shrinking.
The ablation zone should then progressively shrink as early as 2 to 3 weeks after treatment (Fig. 6) [17].
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