Our results (not shown here) indicated that there is no advantage in specifying multiple shrinkage targets.
To further investigate the usefulness of multiple shrinkage targets, we partitioned the genes into 10 groups according to the ranges of and applied the shrinkage separately to each group.
One patient in ZODIAC who received docetaxel alone had a confirmed objective response and 32% shrinkage of target lesions at day 85 (Table 3).
The trial suggests the potential clinical benefit of this multitargeted tyrosine kinase inhibitor in terms of progression arrest and shrinkage of target lesions on fashionable waterfall plots.
As shown in the waterfall plot, tumour shrinkage of target lesions was observed in 22 patients (59.5%) when compared with the baseline tumour measurement according to RECIST 1.1.
Drug-induced tumour shrinkage in the target measurable lesion in these three patients was 86, 76 and 100%, respectively.
It is shown that the shrinkage-PHDF estimates target position and velocity on all tracks with higher estimated precision than the MPF, because MPF requires a modeling setup to accommodate varying numbers of targets, which is very difficult to accomplish in reality.
