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Focus is paid to understand the influence of the volume fraction and properties of inclusions on the shrinkage response.
Since these therapies can induce tumor necrosis and minimal tumor shrinkage, Response Evaluation Criteria in Solid Tumors (RECIST) may not be optimal for predicting clinical outcome.
Nonetheless, the normalized overall shrinkage response was approximately represented by the KWW stretched-exponential growth curve [ 10, 16].
Clinical benefit is stated in general terms and may refer to tumor shrinkage (response), increased PFS or OS, or even enhanced health-related quality of life.
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Tumor shrinkage (partial response or minimal response) obtained by our regimen made surgery for residual disease (with/without liver chemoembolization or liver radiofrequency ablation) feasible in 3 patients.
Nevertheless, subgroups of patients, such as women, nonsmokers, patients with adenocarcinomas, and East Asian patients, tend to have higher objective responses and sometimes exhibit dramatic tumour shrinkage in response to these agents.
Those include fluctuations and fast shrinkage in response to glutamate [10], [47] as well as expansion or shrinkage depending on the intensity of the stimulation [48].
Approximately 10% of patients with non-small cell lung cancer (NSCLC) (those harboring an activating mutation of EGFR) show a dramatic shrinkage in response to the inhibitor gefitinib [39], [40], but this is unlikely to lead to long-term cure.
Knockdown of endogenous PICK1 by shRNA completely blocks spine shrinkage in response to NMDAR activation.
DOI: http://dx.doi.org/10.7554/eLife.06327.014 10.7554/eLiFigure27.015 figure 5—figure supplement 1. Probability of spine growth or shrinkage in response to glutamate uncaging.
Longitudinal tumour size measurements sufficient to assess tumour shrinkage, and response rates were available from 197 patients (88%).
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