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The core of the approach consists of using a TGI model to extract the maximum information regarding disease characteristics (e.g., tumor growth rate) and drug effect (e.g., drug potency) and linking early tumor shrinkage (end-of-cycle 2) to survival in a drug-independent model that can be further leveraged to simulate expected survival differences for new investigational treatments.
Further shrinkage would end design and cost competition, which could bloat future defense budgets and damage military effectiveness.
Since most targeted agents are not expected to produce significant tumour shrinkage, surrogate end points will be required to demonstrate clinical efficacy.
Small values on the entorhinal surfaces can result from AD as well as from small head size or, especially in the elderly, nonspecific global cortical thinning (Capizzano et al 2004) or brain shrinkage, the end point of various diseases, and there is no consensus on the method of normalization of the entorhinal cortex (Lye et al 2006).
The results show that most changes in land use are related to land consumption and soil sealing; however, as urban brownfields provide excellent opportunities for the development of new urban green spaces with superior ES qualities, the shrinkage scenario ended up being very positive in terms of ES improvement.
The shrinkage reflects the end of an era for JPL.
In uninfected cells, shouldn't we see some minus end shrinkage?
The length of a filament, L, is related to its capped time τc and uncapped time tuc by
As a result there is a lack of information on the sequence of molecular events that leads to the growth and shrinkage of microtubule ends.
He speculated that perhaps this was because "even the most imaginative fashion designers shrank from suggesting the kind of frock that will be worn in 1932, since, at the present rate of shrinkage at both ends, frocks may travel far in 11 years".
Many filaments displayed non-uniform intensity (highlighted by arrows), which we used as stationary points to monitor growth and shrinkage of the ends independent of filament diffusion.
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