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Furthermore, histological grade, which strongly reflects proliferation, shows prognostic value only in the ER-positive subgroup (Additional file 5: Figure S4B; ER + p = 0.0002 vs ER- p = 0.57).
Computer determined extent of immunohistochemical staining of the extensively studied biomarker Ki-67 shows prognostic value comparable to visually assessed Ki-67 in a comprehensive series of patients with breast cancer.
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Glucose metabolic activity measured by [18F]-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) has shown prognostic value in multiple malignancies, but results are often confounded by the inclusion of patients with various disease stages and undergoing various therapies.
Conclusions Our studied did not show prognostic value with low levels of serum IgG within 24 hours from SS or SSh onset.
50, 51 Low TS expression from pretherapeutic biopsies showed prognostic value with respect to impaired CSS.
HER2 amplification showed prognostic value in subgroups of patients, as well as Topo2a.
Several biomarkers have failed to show prognostic value when externally validated in an independent cohort.
High CD44 and CD133 expression showed prognostic value for worse patient survival (P=0.014 and P=0.019, respectively).
CD10 and Bcl-6 did not show prognostic value in EFS.
When stratified by ER status, MAP-tau showed prognostic value in ER-negative but not in ER-positive patients.
Stage and grade showed prognostic value as expected, underlining the representativeness of the patient group (see Figure 2).
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