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In agreement with this, Ephrin-B2a and Fn1 have been shown to collaborate in somite cleft formation and maintenance in zebrafish [29].
On the other hand, mammalian TBLR1 was also shown to collaborate with Siah1 in a novel pathway for β-catenin degradation.
Interestingly, the synergistic relationship is not restricted to TLR2, and Dectin-1 has been shown to collaborate with TLR1 47, −4, −5, −7 and −9 48.
For example, Myc was shown to collaborate with loss of p53 (Blyth et al., 2000) or Arf (Jacobs et al., 1999) in mouse lymphomagenesis.
Moreover, miR-31 was shown to collaborate with human telomerase reverse transcriptase (hTERT) to immortalize normal oral keratinocytes (NOKs), indicating that it might contribute to early stage oral carcinogenesis [ 31].
Significantly, the PcG protein B lymphoma Mo-MLV insertion region 1 oncogene (BMI1) has been shown to collaborate with Harvey rat sarcoma oncogene (H-RAS) to induce an aggressive and metastatic phenotype in a breast cancer model (Hoenerhoff et al, 2009).
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The danger of building back doors like that, for example the Bullrun program where the NSA and GCHQ were shown to be collaborating and weakening the encryption standards that the entire internet relies on, means that when you're accessing your bank account online there could be a secret weakness there that allows our western governments' security services to monitor your bank details.
Certainly, David Cameron and co have shown themselves willing to collaborate with Goldsmith in making his pitch to the capital's voters.
A recently cloned tumour suppressor candidate, p33ING1, has been shown in vitro to collaborate with p53 to execute growth arrest and apoptosis.
And for the preponderance of foodies everywhere, the notion that three of the world's most renowned chefs would want to use their star power, not to open a chain of restaurants or promote another cooking show, but to collaborate with the United Nations may seem puzzling.
It has indeed been shown that the willingness to collaborate is greater among physicians under the age of 50 [ 21].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com