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CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays.
These effects were shown to be sustained for up to 90 weeks (13).
Social memory has been shown to be sustained by the amygdala [54], but also by the hippocampus [47].
The improvements in CRP, PAI-1 antigen, and fibrinogen observed with rosiglitazone combination therapy are also consistent with previous monotherapy data [ 23, 24], and are shown to be sustained.
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While intermittent viremia of less than 200 copies/ml has been shown to be innocuous, sustained low-level viremia has been associated with the emergence of drug resistance [9], [16].
For malignant melanoma the earlier reported temporal increase [ 10] has been shown here to be sustained and concentrated within females aged over 14 years.
However, the reactivated myotubes have been depleted of p21, which has been shown to be required for sustained G2 arrest [30].
This long-term efficacy was shown to be still significantly sustained although lowered at age 24 months for scZDV [7] and at age 18-month for sdNVP but little benefit remained at 18-month using different regimens of scZDV+3TC [3].
Reentry has been shown to be generated and sustained by means of focal activity in AF patients [ 54].
Among the MAPK subfamilies, p38 has been shown to be essential for sustained G2/M arrest and apoptosis induced by various anticancer agents.
There are a number of other different mechanisms which could explain the observed effects of chewing gum, such as facial muscle activation [ 4], as EMG has been shown to be maintained when sustained attention performance declines less [ 40].
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