Interestingly, netrin-1 has been shown to be upregulated in a sizeable fraction of metastatic breast, lung, ovary and pancreatic cancer, in inflammatory-associated-colorectal cancer and in neuroblastoma (Delloye-Bourgeois et al, 2009a; Delloye-Bourgeois et al, 2009b; Dumartin et al, 2010; Fitamant et al, 2008; Papanastasiou et al, 2011; Paradisi et al, 2009).
A sizeable number of these observed methylated loci have also been shown to be associated with decreased gene expression [ 2, 19, 22, 23].
Finally, a sizeable minority of respondents reported that they had encountered challenges in collaboration or were shown to be less interested or skilled in collaboration than other respondents.
For example, height has been shown to be influenced by 700 genes, but just a couple, affecting growth hormone production and use, are known to have a sizeable effect on getting taller.
That audience is likely to be sizeable.
She is now suing for damages which are likely to be sizeable.
Furthermore, the amount of overtreatment in children is also considered to be sizeable but poorly defined.
For such a screener to be effective, one would need to show that there are sizeable individual differences in rare search target detection rates, and one would need to find individual difference variables that were predictive of rare target detection rates.
In addition, autocrine activation of the Wnt/β-catenin pathway was shown to occur in a sizeable fraction of cancers from multiple organs and tissues (see Introduction).
In sizeable percentage of TOMM gene clusters, a flavin mononucleotide (FMN -dependent dehydrogenase (B protein) is encoded, which has been shown to oxidize select azoline rings to azoles [ 7].
