Primary human trophoblasts were previously shown to be resistant to viral infection, and able to confer this resistance to nontrophoblast cells.
CD133-positive colon CSCs were shown to be resistant to the conventional cytotoxic drug FU and the resistance was shown recently to be dependent on Wnt signaling [ 15].
Tumors and tumor portions with low oxygen concentrations (pO2) have been shown to be resistant to radiation therapy.
However, cancer stem cells in colorectal cancer have been shown to be resistant to 5-FU as well as other chemotherapeutic drugs such as oxaliplatin and irinotecan11.
Indeed, cancer stem cells have been shown to be resistant to conventional anticancer drugs through a variety of mechanisms including overexpression of ABC transporters, active DNA-repair capacity, overexpression of antiapoptotic proteins, and elevated autophagy8,9,10.
Mice deficient in CD7 have been shown to be resistant to LPS-induced endotoxic shock syndromes.
The circular form of these sequences was shown to be resistant to nuclease degradation in cellular extracts.
ICC has been shown to be resistant to common chemotherapy, with an unacceptably low response rate [14].
Layers on silica surfaces obtained from aqueous mixtures with maltodextrin at a pH value of 4.8 have recently been shown to be resistant to rinsing with water [13].
Isolates from 4 patients were shown to be resistant to fluconazole and itraconazole when tested in vitro; these same isolates had MICs to voriconazole and posaconazole > or = 2 microg/ml.
Despite its role in fatty acid mobilization, HSL null mice have been shown to be resistant to diet-induced obesity.
