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Both Wnt4 and RankL have been demonstrated to function downstream of Pgr in stimulating lobuloalveolar development and have more recently been shown to be requisite paracrine mediators of the actions of progesterone in the regulation of mammary stem cell number [ 33- 37].
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The electrochemical activation of the graphite surface (HOPGET) prior to layer deposition, has shown to be a requisite for the adsorption of phosphonic acid derivatives onto the newly formed oxide species.
On the other hand, glucose has been shown to be the requisite electron donor for superoxide production by NADPH oxidase [ 23].
To note, the synthesis of GABA by newborn neurons and active cortical neurogenesis by resident progenitors of layer 1 have been recently shown to be a fundamental requisite to restore neuronal function after stroke [33], [51].
Clustering of integrins has been previously shown to be a pre-requisite for integrin activation.
Prior to this, however, these newer test methods must be shown to be scientifically valid and the prediction models must be shown to have the requisite degree of scientific confidence necessary to support regulatory decisions.
In this non-polypoid pathway, APC mutation seems to be requisite but K- ras mutation not.
Similarly, NMDA activation appears to be requisite for gabapentin and pregabalin activity.
The target lipid was synthesized and was shown to form the requisite mesophase at room temperature.
However, dacarbazine has been shown to upregulate the requisite NKG2D ligands on tumor cells for their subsequent elimination by natural killer cells, natural killer T cells, and CD8+ T lymphocytes 32.
Fibrocytes have been shown to promote angiogenesis, which is a requisite for the development and maintenance of new granulation tissue, allowing wound closure and restoration of tissue integrity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com