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These genes were located on 5p that was shown to be gained or amplified by CGH in half of the cell lines.
SPIB has also been shown to be gained and overexpressed in B-cell-like diffuse large B-cell lymphoma (Lenz et al, 2008).
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In previous studies, p110α with hotspot mutations such as E545K and H1047R were shown to be gain-of-function mutations.
In terms of gene discovery, specific genomic regions containing important loci have been shown to be frequently gained or lost [ 7- 11].
Interestingly, the 1ptel-1p31 and 7p22-p15 regions were also shown to be more frequently gained in the MFHs, whereas the 1q32-qtel region was shown to be more frequently gained in the leiomyosarcomas, consistent with our findings.
Mass spectrometry has shown to be effective in gaining structural information of glutenins and globulins directly isolated from seeds [ 23, 28- 30].
This mutation was shown to be crucial for the gained affinity for one of the modules.
So far, pharmaceutical chemoprevention with NSAIDs including aspirin has been shown to be effective but not gained general acceptance due to side effects.
RPN4 has also been shown to be activated by gain-of-function alleles of PDR1 [ 12] and the RPN4 promoter contains a PDRE which is actually bound by Pdr1p in vivo and in vitro [ 2, 29].
The c.489C>T variant (p.His155Tyr), located in the extracellular domain of the receptor involved in ATP binding, has been shown to be a weak gain-of-function (GOF) P2RX7 polymorphism evidenced by increased ATP-dependent calcium influx and ethidium uptake.
Significant increases in the ultimate buckling loads are shown to be possible, with potential gains on the order of 100% as compared to a previously proposed design.
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CEO of Professional Science Editing for Scientists @ prosciediting.com