We find that the human network is shown to be functionally organized, and its function evolves with the topological properties of the network.
Occludin (60kDa), a tetraspan integral membrane protein, was the first TJ-specific protein identified [ 12, 13] in epithelial cells and shown to be functionally important for barrier function [ 14].
Furthermore, dominance and aggressiveness were shown to be functionally dissociated, with the former being modulated by the cholinergic nicotinic system and the latter potentiated by prefrontal NE but only in presence of functional β2*nAChRs.
Also, modules associated with at least two diseases were examined for functional GO term enrichment and were shown to be functionally linked.
The two-source method is shown to be functionally much more stable and entirely independent of the loading terminations.
CTLA-4 was shown to be functionally intact by binding to its natural ligands B7-1 (CD80) and B7-2 (CD86) both in vitro and in situ.
The dye-labeled and surface-immobilized ribozymes used were shown to be functionally indistinguishable from the unmodified free ribozyme in solution.
More importantly, the glycan is in proximity to EV71 binding sites of SCARB2 and the residues interacting with Man8GlcNA2 attached to N325 have been shown to be functionally associated with EV71 VP1 (Chen et al., 2012).
Using this sgRNAs selection system, we further demonstrated successful examples of one sgRNA for generating one gene knockout cell lines where the targeted genes are shown to be functionally defective.
Various sections of the hippocampal formation are shown to be functionally and anatomically distinct.
In human, AKR1B1 was previously shown to be functionally related to the murine AKR1B7 [24].
